Pulsed-wave Ultrasound Hyperthermia Enhanced Nanodrug Delivery Combined with Chloroquine Exerts Effective Antitumor Response and Postpones Recurrence
Identifieur interne : 000501 ( Main/Exploration ); précédent : 000500; suivant : 000502Pulsed-wave Ultrasound Hyperthermia Enhanced Nanodrug Delivery Combined with Chloroquine Exerts Effective Antitumor Response and Postpones Recurrence
Auteurs : Chi-Feng Chiang [Taïwan] ; Yu-Hone Hsu [Taïwan] ; Chih-Chun Liu [Taïwan] ; Po-Chin Liang [Taïwan] ; Shi-Chuen Miaw [Taïwan] ; Win-Li Lin [Taïwan]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Autophagy is found to serve as a surviving mechanism for cancer cells. Inhibiting autophagy has been considered as an adjuvant anti-cancer strategy. In this study, we investigated the anti-tumor effect of combining pulsed-wave ultrasound hyperthermia (pUH) enhanced PEGylated liposomal doxorubicin (PLD) delivery with an autophagy inhibitor chloroquine (CQ). BALB/c mice bearing subcutaneous 4T1 tumor received intravenous injection of PLD (10 mg/kg) plus 15-minute on-tumor pUH on Day 5 after tumor implantation and were then fed with CQ (50 mg/kg daily) thereafter. Prolonged suppression of tumor growth was attained with PLD + pUH + CQ treatment, whereas in PLD + pUH group tumors quickly recurred after an initial inhibition. Treatment with CQ monotherapy had no benefit compared to the control group. Immunohistochemical staining and Western blotting showed that autophagy of cancer cells was blocked for the mice receiving CQ. It indicates that PLD + pUH + CQ is a promising strategy to treat cancer for a long-term inhibition.
Url:
DOI: 10.1038/s41598-019-47345-8
PubMed: 31462676
PubMed Central: 6713759
Affiliations:
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xml:lang="fr">Taïwan</country><wicri:regionArea>Miaoli</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Autophagy is found to serve as a surviving mechanism for cancer cells. 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It indicates that PLD + pUH + CQ is a promising strategy to treat cancer for a long-term inhibition.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kilonsky, Dj" uniqKey="Kilonsky D">DJ Kilonsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaravadi, R" uniqKey="Amaravadi R">R Amaravadi</name></author><author><name sortKey="Kimmelman, Ac" uniqKey="Kimmelman A">AC Kimmelman</name></author><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, Jm" uniqKey="Levy J">JM Levy</name></author><author><name sortKey="Thorburn, A" uniqKey="Thorburn A">A 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Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ba, Mc" uniqKey="Ba M">MC Ba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bartlett, Jj" uniqKey="Bartlett J">JJ Bartlett</name></author><author><name sortKey="Trivedi, Pc" uniqKey="Trivedi P">PC Trivedi</name></author><author><name sortKey="Pulinilkunnil, T" uniqKey="Pulinilkunnil T">T Pulinilkunnil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koleini, N" uniqKey="Koleini N">N Koleini</name></author><author><name sortKey="Kardami, E" uniqKey="Kardami E">E Kardami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jh" uniqKey="Park J">JH Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pelt, J" uniqKey="Pelt J">J Pelt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sun, R" uniqKey="Sun R">R Sun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shao, M" uniqKey="Shao M">M Shao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfram, J" uniqKey="Wolfram J">J Wolfram</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lv, T" uniqKey="Lv T">T Lv</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chiang, Chi Feng" sort="Chiang, Chi Feng" uniqKey="Chiang C" first="Chi-Feng" last="Chiang">Chi-Feng Chiang</name></noRegion><name sortKey="Hsu, Yu Hone" sort="Hsu, Yu Hone" uniqKey="Hsu Y" first="Yu-Hone" last="Hsu">Yu-Hone Hsu</name><name sortKey="Liang, Po Chin" sort="Liang, Po Chin" uniqKey="Liang P" first="Po-Chin" last="Liang">Po-Chin Liang</name><name sortKey="Liang, Po Chin" sort="Liang, Po Chin" uniqKey="Liang P" first="Po-Chin" last="Liang">Po-Chin Liang</name><name sortKey="Lin, Win Li" sort="Lin, Win Li" uniqKey="Lin W" first="Win-Li" last="Lin">Win-Li Lin</name><name sortKey="Lin, Win Li" sort="Lin, Win Li" uniqKey="Lin W" first="Win-Li" last="Lin">Win-Li Lin</name><name sortKey="Liu, Chih Chun" sort="Liu, Chih Chun" uniqKey="Liu C" first="Chih-Chun" last="Liu">Chih-Chun Liu</name><name sortKey="Liu, Chih Chun" sort="Liu, Chih Chun" uniqKey="Liu C" first="Chih-Chun" last="Liu">Chih-Chun Liu</name><name sortKey="Miaw, Shi Chuen" sort="Miaw, Shi Chuen" uniqKey="Miaw S" first="Shi-Chuen" last="Miaw">Shi-Chuen Miaw</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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